![]() ![]() The local poisons service should be contacted for advice: Salicylates are present in aspirin medications and in high concentrations of oil of wintergreen (methyl salicylate: one teaspoon = 7 g of salicylate). For severe poisoning consider emergency hemodialysisto remove the salicylate more quickly and restore acid-base balance and fluid status.Salicylate poisoning is potentially fatal. For moderate intoxications, give IV sodium bicarbonate to alkalinize the urine and promote salicylate excretion by trapping the salicylate in its ionized form. Give IVF to replace fluid losses caused by tachypnea, vomiting, fever. Profound metabolic acidosis, seizures, coma, pulmonary edema, and cardiovascular collapse may occur with severe poisoning.Īfter massive aspirin ingestions, aggressive gut decontamination is advisable, including gastric lavage, repeated doses of activated charcoal, and consideration of whole bowel irrigation. Vomiting and hyperpnea as well as hyperthermia contribute to fluid loss and dehydration. Severe hyperthermia may occur in serious cases. Initial ABG testing often reveals this mixed respiratory alkalosis and metabolic acidosis.Body temperature may be elevated. Metabolic acidosis follows, and an increased anion gap results from accumulation of intracellular lactate as well as excretion of bicarbonate by the kidney to compensate for respiratory alkalosis. The first sign of salicylate toxicity is often hyperventilation and respiratory alkalosisdue to medullary stimulation.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |